Gastrin
- What is gastrin? What is its source? What are its target cells? What are its functions? gastrin is one of the many hormones that stimulates secretion of digestive acid by the parietal cells that lining the stomach. The G cells produced and released the gastric acids in the stomach and the duodenum to allows the stomach to break down proteins swallowed as food and absorb certain vitamins, gastric acids also disinfectant and kills most of the bacteria when entering the stomach with food that reduces the risk of infection in the stomach.
- What causes the release of gastrin? The G cells trigger the release of gastrin in the blood when food enters the stomach, as gastrin level rises in the blood, the stomach will release gastric acid to help digest and break down food.
- What cells produce stomach acid? What is stomach acid? Parietal cells or oxyntic cells are cells that produce stomach acids. Stomach acid is a digestive fluid that has a pH of 1-2 composed of hydrochloric acid, potassium and sodium.
- What systemic (body-wide) condition can occur as a result of too much stomach acid production (usually occurs due to excessive vomiting)?Explain why this happens. Helicobacter pylori or (H. pylori infection), patient with this condition may develop peptic ulcer if there is imbalance between the amount of acid and the mucus defense barrier lining the stomach thus, the amount of imbalance acid will damage the lining ot the stomach, causing the detense mucus barrier to be disrupted and inflammation to the stomach mucosa leading to acid to be increased and excessive vomiting that caused by lost of potassium, sodium, hydrogen and chloride ions in the stomach acid composition. 5. What is Helicobacter pylori? How is it treated?
- Is also known as H. pylori infection that is identified in the gastric antrum of patients with active chronic gastritis and peptic ulcers, which is now recognized as the major cause of gastric cancer. It can be treated by omeprazole and antibiotic treatment.
- What pathological conditions can H. pylori cause in humans? Gastric adenocarcinoma, Chronic Gastritis, gastric cancer gastrointestinal cancers and peptic ulcers
- What did this study assess/evaluate/explore? The study assess that gastrin has a distinct effect on the gastric corpus and antrum n the setting of chronic gastric Helicobacter
- infection. While gastrin is possibly an essential cofactor for gastric corpus carcinogenesis, gastrin deficiency can predispose animals to antral tumorigenesis, and thus any imbalances in gastrin physiology may represent a risk for gastric transformation
- What were the authors' conclusions? There are different effect of gastrin on carcinogenesis (normal cells are transformed into cancer cells) of both the gastric corpus and antrum, suggesting that gastrin is an essential cofactor for gastric corpus carcinogenesis
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